In Pirates of the Caribbean: The Curse of the Black Pearl, Keira Knightley was 17 when she shot the movie and Orlando Bloom was 25.
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In Magic in the Moonlight, Emma Stone was 25 and Colin Firth was 53.
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In Entrapment, there was a whopping 39-year age difference between 29-year-old Catherine Zeta-Jones and 68-year-old Sean Connery.
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In Edge of Tomorrow, Tom Cruise was 20 years older than Emily Blunt.
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In Silver Linings Playbook, Jennifer Lawrence was 22, while Bradley Cooper was 37.
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In WandaVision, Elizabeth Olsen was 31 and Paul Bettany was 49.
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In As Good as It Gets, Jack Nicholson was 60 and Helen Hunt was 34.
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In The Island, Ewan McGregor was 34 and Scarlett Johansson was 20.
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In Lost in Translation, Scarlett Johansson was 18 playing opposite a 52-year-old Bill Murray.
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In Indecent Proposal, Robert Redford was 56 and Demi Moore was 30 when the film was released.
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In A Perfect Murder, there was a 28-year age difference between Michael Douglas and Gwyneth Paltrow.
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In Suicide Squad, Jared Leto was 44 and Margot Robbie was 26.
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In Focus, Margot Robbie was 24 and Will Smith was 46.
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In Ted, Mark Wahlberg was 41 and Mila Kunis was 28.
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And in Ted 2, Mark Wahlberg was 44 and Amanda Seyfried was 29.
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In Poison Ivy, Tom Skerritt was 58, while Drew Barrymore was only 17.
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In Third Person, Liam Neeson was a full 32 years older than his love interest, played by Olivia Wilde.
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In Autumn in New York, Richard Gere was 50 and Winona Ryder was 28.
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In In the Line of Fire, Clint Eastwood and Rene Russo had a 24-year age gap.
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In Six Days, Seven Nights, Anne Heche was 29 when she played 55-year-old Harrison Ford's love interest.
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In The Woman in Red, Gene Wilder was 27 years older than Kelly LeBrock.
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In Crazy Heart, Jeff Bridges was 60 while filming, and Maggie Gyllenhaal was 32.
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In Gangster Squad, 25-year-old Emma Stone played the love interest of both 53-year-old Sean Penn and 33-year-old Ryan Gosling.
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In Birdman, Michael Keaton had 31 years on his love interest, played by Andrea Riseborough.
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In Blame It on Rio, 50-year-old Michael Caine dated his best friend's daughter, played by 18-year-old Michelle Johnson.
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In The Phantom of the Opera, Emmy Rossum was 17 when she played the love interest of 33-year-old Gerard Butler and 30-year-old Patrick Wilson.
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In Never Have I Ever, Maitreyi Ramakrishnan was 19 and Darren Barnet was 30 when Season 2 premiered.
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In Singin' in the Rain, Debbie Reynolds was 19 and Gene Kelly was 40.
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In That '70s Show, Mila Kunis was 15 and Ashton Kutcher was 20 when the pilot aired.
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In White Christmas, Rosemary Clooney was 26 and Bing Crosby was 51.
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In Flight, Denzel Washington was 57 and Kelly Reilly was 35.
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In Boy Meets World, Rider Strong was 17 and Trina McGee Davis was 28 when they played Shawn and Angela.
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In Funny Face, Fred Astaire was 30 years older than Audrey Hepburn.
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In Get Smart, Anne Hathaway was 25 and Steve Carell was 45 when they played spies turned lovers.
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In Riverdale, Ashleigh Murray was 31 when her character dated Archie, played by 22-year-old KJ Apa.
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In Another Cinderella Story, Selena Gomez was 16 and Drew Seeley was 26.
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In Charade, Cary Grant was 59 when he played 34-year-old Audrey Hepburn's love interest.
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In The Breakfast Club, Molly Ringwald was 16, and despite playing a high school student, Judd Nelson was 25 in real life.
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In Elf, Will Ferrell was 36 and his love interest, Zooey Deschanel, was 23.
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In The Squid and the Whale, 23-year-old Anna Paquin played a student who comes on to 50-year-old Jeff Daniels. Just nine years earlier, Anna played Jeff's daughter in Fly Away Home.
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In Ghost Rider, Nicolas Cage and Eva Mendes were 10 years apart in age, despite the fact that they are supposed to be former high school sweethearts.
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In The Lord of the Rings: The Fellowship of the Ring, Viggo Mortensen was 43 and Liv Tyler was 24.
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In Lost, Evangeline Lilly was at least a decade younger than her love interests, played by Matthew Fox and Josh Holloway.
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In Always Be My Maybe, Keanu Reeves was 17 years older than Ali Wong when he played her A-list boyfriend.
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In He Got Game, Denzel Washington was 21 years older than Milla Jovovich.
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In Seeking a Friend for the End of the World, Steve Carell and Keira Knightley fell in love, with a 22-year age gap between them.
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And finally, Warren Beatty wooed Halle Berry despite being 30 years her senior in Bulworth.