Halle Berry made Storm an iconic X-Men character before trying her hand at a different version of Catwoman in a solo movie.
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Zachary Levi was Fandral, one of Thor's friends, before becoming the leading man of DC's Shazam!
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Tom Hardy was unrecognizable behind a mask in The Dark Knight Rises as Bane before he became Venom.
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Idris Elba went from playing Heimdall in the MCU to being Bloodsport, leader of the Suicide Squad in James Gunn's film.
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Before David Harbour was Alexei Shostakov/the Red Guardian in Black Widow, he appeared in 2016's Suicide Squad as a notational security advisor.
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Michelle Pfeiffer appeared in Ant-Man and the Wasp as Janet van Dyne years after bringing the role of Catwoman to the big screen for DC.
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J.K. Simmons was known for years as the man asking Peter Parker for photos of Spider-Man. He then appeared as James Gordon in the DCEU before reprising his role as J. Jonah Jameson.
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Joe Manganiello was Spider-Man's high-school bully Flash Thompson before appearing as Deathstroke in the DC universe for Zack Snyder.
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Ben Affleck was Daredevil before he put on the cape and cowl to play Batman in a few DC movies.
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Willem Dafoe played Spider-Man villain Green Goblin before being a mentor to Aquaman.
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Josh Brolin has played Thanos and Cable in Marvel movies, but he first played Jonah Hex for DC.
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Before Michael Fassbender played young Magneto, he appeared in Jonah Hex as a villain named Burke.
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James Marsden was Scott Summers/Cyclops in the X-Men films and he also appeared in Superman Returns, playing Lois Lane’s fiancée.
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Angela Bassett joined the MCU as royalty in Black Panther after playing a version of Amanda Waller in DC's Green Lantern.
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David Dastmalchian has appeared in multiple Marvel and DC projects from Ant-Man to The Dark Knight in minor roles. He's finally playing a leading man in The Suicide Squad, Polka-Dot Man.
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Before Ryan Reynolds killed it as Deadpool he starred in one of the worst super hero movies as Green Lantern.
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Randall Park was Dr. Stephen Shin in Aquaman in addition to playing Jimmy Woo for the MCU.
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Zazie Beetz played Domino in Deadpool 2 before before her part in Joker.
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Ben Mendelsohn is the friendly Skrull Talos in the MCU, but before that, he appeared in The Dark Knight Rises, and he was a real ##ck.
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Jared Leto will soon play Marvel vampire Morbius after a, let’s just say questionable, take on the Joker.
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Chris Pine voiced Peter Parker in Spider-Man: Into the Spider-Verse in between his time as Steve Trevor in the Wonder Woman franchise.
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Bryan Tyree Henry has been in both Into the Spider-Verse and Joker. He'll next appear in Marvel's Eternals as Phastos.
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Tilda Swinton played a gender and race swapped Ancient One in Doctor Strange after her role as an androgynous angel Constantine.
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Rachel Weisz also jumped to the MCU in Black Widow years after appearing in Constantine.
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Michael Rooker plays Yondu in the Guardians franchise and Rooker gets implanted with a chip as Savant in The Suicide Squad.
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Sean Gunn, brother to director James Gunn, plays the onset stand-in for Rocket Raccoon in the Guardians of the Galaxy movies. He also plays the Ravager, Kraglin, and now plays Weasel in The Suicide Squad, as well as a small cameo as Calendar Man.
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Sylvester Stallone plays a leader of the Ravagers in Guardians of the Galaxy Vol. 2. Stallone also voices King Shark in The Suicide Squad.
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Laurence Fishburne went from playing Perry White at The Daily Planet in "Man of Steel" and the DCEU to playing scientist Bill Foster in Ant-Man and the Wasp. He also voiced Silver Surfer in Fantastic 4: Rise of the Silver Surfer.
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Djimon Hounsou plays Korath in Guardians of the Galaxy, Midnite in Constantine, King Ricou in Aquaman, and the Wizard in Shazam.
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Adewale Akinnuoye-Agbaje portrayed a dark elf named Algrim in Thor: The Dark World. and Killer Croc in Suicide Squad.
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Pom Klementieff is Mantis in the MCU and has a small cameo as a dancer in The Suicide Squad.
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Thor: Ragnarok director Taika Waititi voiced Korg in the MCU after he appeared in Green Lantern years prior and makes a small appearance in The Suicide Squad.
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Tommy Lee Jones appeared as a colonel in Captain America: The First Avenger. But long before that he played Two-Face in the underrated (seriously!) Batman Forever.